苗庆庆，教授、博士生导师
电话：0512-65880052
传真：0512-65884380
电子邮箱：qqmiao@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号, 邮编215123
课题组网页：https://www.x-mol.com/groups/QingqingMiao
个人简历：
苗庆庆，苏州大学放射医学与防护学院特聘教授，博士生导师，国家重大人才工程A类青年项目入选者，江苏特聘教授，江苏省双创博士人才项目，主持国家自然科学基金青年基金，江苏省青年基金各1项。2010年获得安徽大学化学专业学士学位，2015年获得中国科学技术大学分析化学专业博士学位。2015年至2018年在新加坡南洋理工大学化学与生物医学工程学院完成博士后研究。2018年11月加入苏州大学放射医学与辐射防护国家重点实验、放射医学与防护学院分子影像与核医学研究中心。主要从事发展核医学探针、光学探针、纳米技术等用于疾病诊断、治疗及精准医学等的研究。研究领域涉及分子影像，纳米医学，转化医学等交叉领域。迄今为止在Nat. Biotechnol., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mat.等国际核心学术期刊上发表研究论文30多篇。
研究方向：
1.放射性核素探针的设计、合成及其在重大疾病早期诊断、高效治疗等方面的应用基础研究：针对肿瘤高特性靶点和普适性肿瘤微环境开发高性能核素探针；通过合理调控探针的结构，亲疏水性，分子量，自组装等性能参数，调控核素探针的体内行为，提高探针诊疗效果；
2.高灵敏、高特异性探针设计及生物医学应用：针对生物蛋白酶、pH、 ROS等与生命活动相关的生物标志物设计激活光学探针，用于肿瘤等疾病的早期诊断。
科研项目：
1.国家自然科学基金面上项目，2023.1-2026.12，54万，主持
2.姑苏创新创业青年领军人才，2021.1-2023.12，50万，主持
3.国家重大人才工程A类青年项目，2020.1-2022.12，200万，主持
4.国家自然科学基金青年项目， 2020.1-2022.12，21万，主持
5.2019江苏特聘教授，2019.9-2022.8，100万，主持
6.江苏省青年基金项目，2019.7-2022.6，20万，主持
代表性论著：
1. Hui Zhou, Yuan Zhang, Ruru Zhang, Min Zhao, Wan Chen, Yinghua Liu, Yue Jiang, Qing Li, Qingqing Miao*, Minyuan Gao*. Tumor Microenvironment-Activatable Molecular Pro-theranostic Agent for Photodynamic and Immunotherapy of Cancer. Adv. Mater. 2023, 2211485.
2. Wan Chen, Yue Jiang, Min Zhao, Yi An, Yuan Zhang, Li Yang, Qingqing Miao*.1O2-Relevant Afterglow Luminescence of Chlorin Nanoparticles for Discriminative Detection and Isotopic Analysis of H2O and D2O. Anal. Chem. 2023, 95, 5340-5345.
3. Jia Miao#, Minqian Miao#, Yue Jiang, Min Zhao,Qing Li*, Yuan Zhang,Yi An, Kanyi Pu*, Qingqing Miao*. Activatable NIR-II Fluorescent Reporter for in Vivo Imaging of Amyloid-β Plaques. Angew. Chem. Int. Ed.2023, e202216351.
4. Shenhua Li#, Qing Li#,*, Wan Chen,Yi An, Peixin Chen, Yan Wu, Guanglin Wang, Yayi He,Qingqing Miao*. A Renal-Clearable Activatable Molecular Probe for Fluoro-Photacoustic and Radioactive Imaging of Cancer. Small, 2022, 2201334.
5. Jieli Zhu#, Ran Zhu#, Qingqing Miao*. Polymeric agents for activatable fluorescence, self-luminescence and photoacoustic imaging. Biosens. Bioelectron.2022, 210, 114330.
6. Wan Chen,Yuan Zhang,Qing Li*, Yue Jiang, Hui Zhou, Yinghua Liu,Qingqing Miao*, Minyuan Gao*. Near-Infrared Afterglow Luminescence of Chlorin Nanoparticles for Ultrasensitive In Vivo Imaging. J. Am. Chem. Soc. 2022, 144, 6719-6726.
7. Yinghua Liu#, Jianfeng Zeng#, Qing Li*, Zhuorun Song, Minqian Miao, Min Zhao, Qingqing Miao*, Minyuan Gao*. An APN-activated chemiluminescent probe for image-guided surgery of malignant tumors. Adv. Opt. Mater. 2022, 2102709.
8. Yuan Zhang#, Guanglin Wang#, Qing Li*, Yue Jiang, Wan Chen, Min Zhao, Gaoling Liang, Qingqing Miao*, Acidity-Activated Charge Conversion of 177Lu-labeled Nanoagent for the Enhanced Photodynamic Radionuclide Therapy of Cancer. ACS Appl. Mater. Interfaces, 2022, 14, 3875-3884.
9. Yan Zhang#,*, Shasha He#, Wan Chen, Yinghua Liu, Xuefei Zhang, Qingqing Miao*, Kanyi Pu*. Activatable Polymeric Nanoprobe for Near‐Infrared Fluorescence and Photoacoustic Imaging of T Lymphocytes. Angew. Chem. Int. Ed., 2021, 60, 5921-5927.
10. Wu Cai#, Guohua Fan#, Hui Zhou#, Lei Chen, Jianxian Ge, Baoxing Huang, Dandan Zhou, Jianfeng Zeng*, Qingqing Miao*, Chunhong Hu*. Self-Assembled Hybrid Nanocomposites for Multimodal Imaging-Guided Photothermal Therapy of Lymph Node Metastasis. ACS Appl. Mater. Interfaces, 2020, 12, 49407-49415.
11. Qing Li#, Shenhua Li#, Shasha He, Wan Chen, Penghui Cheng, Yan Zhang, Qingqing Miao*, and Kanyi Pu*. An Activatable Polymeric Reporter for Near-Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer. Angew. Chem. Int. Ed., 2020, 59, 7018 – 7023 (Cover).
12. Qing Li, Jianfeng Zeng, Qingqing Miao* and Mingyuan Gao. Self-Illuminating Agents for Deep-Tissue Optical Imaging. Front. Bioeng. Biotechnol. 2019, 7, 326.
13. Qingqing Miao, and Kanyi Pu*. Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics. Adv. Mater., 2018, 30, 1801778.
14. Qingqing Miao#, David C. Yeo#, Christian Wiraja, Jianjian Zhang, Xiaoyu Ning, Chenjie Xu,* and Kanyi Pu*. Near‐Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid. Angew. Chem. Int. Ed., 2018, 57, 1256 –1260.
15. Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V Jokerst, and Kanyi Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nat. Biotechnol., 2017, 35, 1102.
16. Qingqing Miao#, Yan Lyu#, Dan Ding and Kanyi Pu*. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH. Adv. Mater., 2016, 28, 3662-3668.
17.Qingqing Miao, and Kanyi Pu*. Emerging designs of activatable photoacoustic probes for molecular imaging. Bioconjugate Chem., 2016, 27, 2808-2823.
18. Qingqing Miao, Qing Li, Qingpan Yuan, Lingli Li, Zijuan Hai, Shuang Liu, and Gaolin Liang*. Discriminative fluorescence sensing of biothiols in vitro and in living cells.Anal. Chem., 2015, 87, 3460-3466.
19. Qingqing Miao, ZiyeWu, Zijuan Hai, Changlu Tao, Qingpan Yuan, Yadi Gong, Yafeng Guan, Jun Jiang* and Gaolin Liang*. Bipyridine hydrogel for selective and visible detection and absorption of Cd2+. Nanoscale, 2015, 7, 2797-2804.
20. Qingqing Miao, Chunying Yin, Maolin Xie, Yufeng Luo, Zijuan Hai, Qingpan Yuan, Jun Jiang and Gaolin Liang*. Gathering nanorings via Fe 2+–bipyridine coordination. Chem. Commun., 2015, 51, 11045-11047.
专利：
1. Polymer nanoparticles for afterglow molecular imaging, US Patent App. 16/633,887, 2021.
2.一种可激活光学分子探针及其制备方法与应用，专利号，ZL 2020 1 0081216.0;
3.一种可区分检测生物硫醇的荧光探针及其制备方法，专利号： ZL 2015 1 0016547.5;
4.一种可检测和去除镉的超分子水凝胶凝胶因子及其制法，专利号：ZL 2014 1 0636033.5;
5.一种单光子发射计算机断层成像显像剂及其制备方法，专利号：ZL 2012 1 0164547.6。
荣誉奖励:
1.海外高层次人才，2020
2.江苏省特聘教授，2019
3.江苏省双创博士，2019
课程教学及招生信息：
本课题组热忱欢迎有志从事科研工作的本科/硕士/博士研究生以及博士后到课题组学习工作。欢迎具有化学、生物和医学背景的同学加盟。如有兴趣，请联系qqmiao@suda.edu.cn。诚挚欢迎各位加入我们课题组!