邓超

时间:2020-10-23来源:必赢国际437官方点击:1841

邓超  教授  博士生导师

1975.11.15出生

电话:0512-65884933                            

传真:0512-65884933

邮箱:cdeng@suda.edu.cn

通讯地址:苏州工业园区仁爱路199号苏州大学912号楼708室,邮编215123

 

个人简历:

邓超,博士,苏州大学教授,博导。江苏省先进功能高分子材料设计及应用重点实验室副主任,苏州大学-博瑞医药创新靶向药物研究院副院长,全球高被引科学家。20067月在中国科学院长春应用化学研究所高分子化学与物理专业获博士学位(导师:景遐斌研究员、陈学思院士)。20068月—20105月在加拿大渥太华大学眼睛所、心脏所和细胞分子生物医学系从事博士后研究。20106月起受聘为苏州大学副教授,2014年晋升为教授。在国际主流期刊如Adv. Sci., Nano Today, Small, Biomaterials, Adv. Healthcare Mater., Chem. Mater., J. Control. Release, Macromolecules, Acta Biomater., Prog. Polym. Sci., Adv. Drug Delivery Rev.等上发表论文100多篇,被引用10000多次,H-因子57。多篇论文被MaterialsViewChina,中国聚合物网和高分子科技等作为研究亮点进行专题报道。受邀担任Frontier In Chemistry期刊的评审编辑,Nanomaterials期刊编委。申请中国发明专利16项和国际发明专利2项,授权中国发明专利13项。担任了五届“新型高分子材料与控制释放国际会议”(SIPCD 2010, 2012, 2014, 2016, 2018)”的秘书长,并多次在国际会议上作报告。现主持一项国家自然科学基金面上项目,参与两项国家重点研发计划项目。


主要研究方向:

功能性聚多肽材料的设计合成

聚合物纳米药物用于肿瘤的靶向高效治疗

/纳米凝胶的构建及其在蛋白质药物控释中的应用

肿瘤免疫治疗


在研项目:

1.项目来源: 国家自然科学基金面上项目;项目名称: 构建智能不对称聚肽囊泡共载亲疏水药物用于耐药肿瘤的靶向协同治疗;编号: 51973149;立项年度:2020.1—2023.12;经费: 60万元;在研;项目负责人。

2.项目来源: 国家重点研发计划项目;项目名称: 生物大分子药物输送聚合物载体材料;编号: 2021YFB3800900;立项年度:2021.12—2025.11;经费: 2700万元;在研;参与。

3.项目来源: 国家重点研发计划项目;项目名称: 细胞功能调控的超敏活性生物材料;编号: 2022YFB3804603;立项年度:2022.11—2025.10;经费: 1300万元;在研;参与。


代表性论著:

1.J.G. Xie, X.F. Zhao, P. Zhang, Y.Y. Zhang, R. Cheng, Z.Y. Zhong*, and C. Deng*, Codelivery of BCL2 and MCL1 inhibitors enabled by phenylboronic acid-functionalized polypeptide nanovehicles for synergetic and potent therapy of acute myeloid leukemia, Adv. Sci. 2023, 2204866.

2.Y.Y. Liu, J.G. Xie, X.F. Zhao, Y.Y. Zhang, Z.Y. Zhong*, and C. Deng*, A polymeric IDO inhibitor based on poly(ethylene glycol)-b-poly(L-tyrosine-co-1-methyl-D-tryptophan) enables facile trident cancer immunotherapy, Biomater. Sci. 2022, 10, 5731.

3.Q. Zhang, Y.Y. Liu, Y.C. Fei, J.G. Xie, X.F. Zhao, Z.Y. Zhong*, and C. Deng*, Phenylboronic acid-functionalized copolypeptides: Facile synthesis and responsive dual anticancer drug release, Biomacromolecules 2022, 23, 2989-2998.

4.Q.Y. Fan, Y.Y. Liu, G.H. Cui, Z.Y. Zhong*, and C. Deng*, Brain delivery of Plk1 inhibitor via chimaeric polypeptide polymersomes for safe and superb treatment of orthotopic glioblastoma, J. Control. Release2021, 329, 1139-1149.

5.Z.Q. Zhang, Q. Zhang, J.G. Xie, Z.Y. Zhong*, and C. Deng*, Enzyme-responsive micellar JQ1 induces enhanced BET protein inhibition and immunotherapy of malignant tumors, Biomater. Sci. 2021, 9, 6915-6926.

6.C. Deng*,Q.Zhang, J.K. Guo, X.F. Zhao, and Z.Y. Zhong*, Robust and smart polypeptide-based nanomedicines for targeted tumor therapy, Adv. Drug Delivery Rev. 2020, 160, 199-211.

7.H.M. Fang, X.F. Zhao, X.L. Gu, H.L. Sun, R. Cheng, Z.Y. Zhong*, and C. Deng*, CD44-targeted multifunctional nanomedicines based on a single-component hyaluronic acid conjugate with all-natural precursors: construction and treatment of metastatic breast tumors in vivo, Biomacromolecules2020, 21, 104-113.

8.S. Li#, M. Qiu#, J.K. Guo, X.F. Zhao, Z.Y. Zhong*, and C. Deng*, Coating-sheddable CD44-targeted PLGA nanomedicines fabricated by using photo-click-crosslinkable surfactant, Adv. Therap.2020, 3, 1900160.

9.X.L. Gu, Z.H. Zhu, Q.Y. Fan, Y.H. Wei, G.L. Wang, F.H. Meng, Z.Y. Zhong*, and C. Deng*, Nanoagents based on poly(ethylene glycol)-b-poly(L-thyroxine) block copolypeptide for enhanced dual-modality imaging and targeted tumor radiotherapy, Small2019, 1902577.

10.X.L. Gu, Y.H. Wei, Q.Y. Fan, H.L. Sun, R. Cheng, Z.Y. Zhong*, and C. Deng*, cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo, J. Control. Release2019, 301, 110-118.

11.K. Huang, Y.H. He, Z.H. Zhu, J.K. Guo, G.L. Guang, C. Deng*, and Z.Y. Zhong*, Small, traceable, endosome-disrupting, and bioresponsive click nanogels fabricated via microfluidics for CD-targeted cytoplasmic delivery of therapeutic proteins, ACS Appl. Mater. Interfaces2019, 11, 22171-22180.

12.M. Qiu, J. Ouyang, Y.H. Wei, J. Zhang, Q. Lan, C. Deng*, and Z.Y. Zhong*, Selective cell penetrating peptide-functionalized envelope-type chimeric lipopepsomes boost systemic RNAi therapy for lung tumors, Adv. Healthcare. Mater.2019, 8, 1900500.

13.M. Qiu, H.L. Sun, F.H. Meng, R. Cheng, J. Zhang, C. Deng*, and Z.Y. Zhong*, Lipopepsomes: A novel and robust family of nano-vesicles capable of highly efficient encapsulation and tumor-targeted delivery of doxorubicin hydrochloride in vivo, J. Control. Release2018, 272, 107-113.

14.J. Chen, K. Huang, Q.J. Chen, C. Deng*, J. Zhang, and Z.Y. Zhong*, Tailor-Making Fluorescent Hyaluronic Acid Microgels via Combining Microfluidics and Photoclick Chemistry for Sustained and Localized Delivery of Herceptin in Tumor, ACS Appl. Mater. Interfaces2018, 10, 3929-3937.

15.M. Qiu, Z.Q. Zhang, Y.H. Wei, H.L. Sun, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Small-sized and robust chimaeric lipopepsomes: A simple and functional platform with high protein loading for targeted intracellular delivery of protein toxin in vivo, Chem. Mater. 2018, 30, 6831-6838.

16.M. Qiu, J. Ouyang, H.L. Sun, F.H. Meng, R. Cheng, J. Zhang, L. Cheng, Q. Lan, C. Deng*, and Z.Y. Zhong*, Biodegradable Micelles Based on Poly(ethylene glycol)-b-Polylipopeptide Copolymer: A Robust and Versatile Nanoplatform for Anticancer Drug Delivery, ACS Appl. Mater. Interfaces2017, 9, 27587-27595.

17.J. Chen, J. Ouyang, Q.J. Chen, C. Deng*, F.H. Meng, J. Zhang, R. Cheng, Q. Lan, and Z.Y. Zhong*, EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo, ACS Appl. Mater. Interfaces2017, 9, 24140-24147.

18.J.T. Wu, J. Zhang, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, Robust, Responsive and Targeted PLGA Anticancer Nanomedicines by Combining Reductively Cleavable Surfactant and Covalent Hyaluronic Acid Coating, ACS Appl. Mater. Interfaces2017, 9, 3985-3994.

19.J.T. Wu, C. Deng*, F.H. Meng, J. Zhang, H.L. Sun, and Z.Y. Zhong*, Hyaluronic Acid Coated PLGA Nanoparticulate Docetaxel Effectively Targets and Suppresses Orthotopic Human Lung Cancer, J. Control. Release2017, 259, 76-82.

20.J. Chen, Y. Zou, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Multifunctional Click Hyaluronic Acid Nanogels for Targeted Protein Delivery and Effective Cancer Treatment In Vivo, Chem. Mater.2016, 28, 8792-8799.

21.S. Li, J. Zhang, C. Deng*, F.H. Meng, L. Yu, and Z.Y. Zhong*, Redox-Sensitive and Intrinsically Fluorescent Photoclick Hyaluronic Acid Nanogels for Traceable and Targeted Delivery of Cytochrome C to Breast Tumor In Mice, ACS Appl. Mater. Interfaces2016, 8, 21155-21162.

22.B.F. Sun, C. Deng*, F.H. Meng, J. Zhang, and Z.Y. Zhong*, Robust, Active Tumor-Targeting and Fast Bioresponsive Anticancer Nanotherapeutics Based on Natural Endogenous Materials, Acta Biomaterialia 2016, 45, 223-233.

23.C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications, Prog. Polym. Sci.2014, 39, 330-364.

24.C. Deng, Y.J. Jiang, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Biodegradable Polymeric Micelles for Targeted and Controlled Anticancer Drug Delivery: Promises, Progress and Prospects. Nano Today2012, 7, 467-480.


荣誉奖励:

1.2022年,全球高被引科学家(跨学科领域,科睿唯安(Clarivate Analytics))

2.2021年,全球高被引科学家(跨学科领域,科睿唯安(Clarivate Analytics))

3. 2018年,全球高被引科学家(药理学和毒理学领域,科睿唯安(Clarivate Analytics))4. 2012-2013年,苏州市自然科学优秀学术论文二等奖

5. 2010-2011年,苏州市高等院校、科研院所紧缺高层次人才资助

6. 2010-2012,加拿大心脏及中风基金委研究奖学金


课程教学及招生信息:

1. 硕士生课程:《生物医用高分子》

2. 本科生课程:《生物医学工程学》,《功能材料应用和前沿》,《精细化工实验》

3. 招生信息:欢迎具有材料,化学和放射医学等背景的学生报考博士和硕士研究生