杨凯 ，教授、博士生导师
电话：0512-65882925
邮箱：kyang@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号苏州大学放射医学与防护学院401楼319室, 邮编215123
杨凯，苏州大学教授，国家优秀青年科学基金和江苏省优秀青年基金获得者（2018）。2006年获得安徽工程大学生化工程系工学学士学位，2009年获得苏州大学基础医学与生物科学学院理学硕士学位，2013年获得苏州大学功能纳米与软物质研究院理学博士学位，2012年至2013年在美国国立卫生研究院进行博士联合培养。2014年1月加入苏州大学医学部放射医学与防护学院，被聘为副教授，硕士生导师。2018年9月，被聘为特聘教授。近年来在纳米生物医学材料与肿瘤纳米技术领域从事研究，共发表学术论文130余篇，论文总他引用超过17000次，SCI H-index = 63。2018-2021年连续入选科睿-唯安发布的“全球高引用科学家名录”（Highly Cited Researchers）（材料学）。2016年获得江苏省科技进步一等奖（第二完成人）；2015年获得教育部自然科学二等奖（第三完成人）；苏州市高等院校、科研院所紧缺高层次人才。
主要研究方向：
本课题组的研究领域是纳米医学与放射医学，这是一门跨越材料、化学、生物医学和放射医学的交叉学科。我们的目标是开发新型功能纳米材料，研究其在生命体系中的行为，并利用纳米材料独特的物理与化学性质以发展新型多模态生物影像技术、靶向药物输送技术、以及肿瘤物理联合治疗，从而探索癌症的诊断与治疗的新思路与新方法。主要研究方向如下：
1.纳米放射医学
2.基于功能纳米材料的肿瘤放射治疗
3.生物纳米材料与肿瘤微环境调控及其放射治疗
4.基于生物材料的肿瘤放射免疫联合治疗
科研项目：
1. 项目来源：国家自然科学基金委面上项目，项目名称：基于细菌载体的肿瘤放射免疫联合治疗的应用基础研究；项目编号：321713822 ；立项年度：2022-01-01 - 2025-12-31；59万元, 在研, 项目负责人
2. 项目来源：国家自然科学基金委-大科学装置联合基金重点项目，项目名称：海藻酸钠/咪喹莫特微球在肿瘤重离子免疫联合治疗中应用基础研究；编号：U1932208；立项年度：2020.1-2023.12；300万；在研；项目负责人。
3. 项目来源：国家自然科学基金委-优秀青年科学基金项目，项目名称：功能纳米材料在肿瘤放疗中的应用探索；编号：31822022；立项年度：2019.1-2021.12；130万；结题；项目负责人。
4. 项目来源：江苏省科技厅-优秀青年科学基金项目，项目名称：功能纳米材料在肿瘤放射治疗中的应用；编号：BK20180094；立项年度：2018.7-2021.6；50万；结题；项目负责人
代表性论文：
1.Pei Pei, Wenhao Shen, Yu Zhang, Yanxiang Zhang, Zhongyuan Qi, Hailin Zhou, Teng Liu,
Liang Sun*, Kai Yang*, Radioactive nano-oxygen generator enhance anti-tumor radio-immunotherapy by regulating tumor microenvironment and reducing proliferation, Biomaterials, 2022, 280, 121326.
2.Jing Zhong, Qin Zhang, Zheng Zhang, Kexin Shi, Yuanchen Sun, Teng Liu, Jun Lin*, Kai Yang*, Albumin mediated reactive oxygen species scavenging and targeted delivery of methotrexate for rheumatoid arthritis therapy, Nano Research, 2022, 15, 153-161.
3.Pei Pei, Wenhao Shen, Hailin Zhou, Yuanchen Sun, Jing Zhong, Teng Liu, Kai Yang*, Radionuclide labeled gold nanoclusters boost effective anti-tumor immunity for augmented radio-immunotherapy of cancer, Nano Today, 2021, 38, 101144.
4.Pei Pei,Teng Liu,Wenhao Shen,Zhuang Liu *, Kai Yang *, Biomaterial-mediated internal
radioisotope therapy, Materials Horizons, 2021,8, 1348.
5.Xuan Yi,* Mengling Shen, Xinpei Liu, Jingyu Gu, Zewei Jiang, Lixing Xu, and Kai Yang*, Diagnostic Radionuclides Labeled on Biomimetic Nanoparticles for Enhanced Follow-Up Photothermal Therapy of Cancer, Adv. Healthcare Mater. 2021, 2100860.
6.Xuan Yi, Hailin Zhou, Yu Chao, Saisai Xiong, Jing Zhong, Zhifang Chai, Kai Yang*, Zhuang Liu*, Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer Science Advances, 2020; 6: eaba3546.
7.Xuan Yi*, Hailin Zhou, Zheng Zhang, Saisai Xiong, Kai Yang*, X-rays-optimized delivery of radiolabeled albumin for cancer theranostics, Biomaterials, 2020, 233, 119764.
8.Debabrata Maiti, Jing Zhong, Zheng Zhang, Hailin Zhou,Saisai Xiong, Ziliang Dong, Sarvendra Kumar, Zhuang Liu, Kai Yang *, Polyoxomolybdate (POM) nanoclusters with
radiosensitizing and scintillating properties for low dose X-ray inducible radiation-radiodynamic therapy, Nanoscale Horiz., 2020, 5, 109-118.
9.Zheng Zhang, Jingrong Yang, Qingqing Min, Chenjie Ling, Debabrata Maiti, Jiaying Xu,*
Liqiang Qin,* and Kai Yang*, Holo-Lactoferrin Modifed Liposome for Relieving Tumor
Hypoxia and Enhancing Radiochemotherapy of Cancer, Small 2019, 1803703.
10.Yu Chao, Ligeng Xu, Chao Liang, Liangzhu Feng, Jun Xu, Ziliang Dong, Longlong Tian, Xuan Yi, Kai Yang*, Zhuang Liu*, Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses, Nature Biomedical. Engineering, 2018, 2, 611-621.
11.Longlong Tian, Xuan Yi, Ziliang Dong, Jun Xu, Chao Liang, Yu Chao, Yaxing Wang, Kai Yang*, Zhuang Liu*, Calcium Bisphosphonate Nanoparticles with Chelator-Free Radiolabeling to Deplete Tumor-Associated Macrophages for Enhanced Cancer Radioisotope Therapy, ACS Nano 2018, 12, 11541-11551.
12.Yu Chao, Chao Liang, Yu Yang, Guanglin Wang, Debabrata Maiti, Longlong Tian, Fei Wang, Wei Pan, Song Wu*, Kai Yang*, Zhuang Liu*, Highly Effective Radioisotope Cancer Therapy with a Non-Therapeutic Isotope Delivered and Sensitized by Nanoscale Coordination Polymers, ACS Nano 2018, 12, 7519-7528.
13.Xuan Yi, Meiyun Xu, Hailin Zhou, Saisai Xiong, Rui Qian, Zhifang Chai, Li Zhao*, Kai Yang*, Ultrasmall Hyperbranched Semiconducting Polymer Nanoparticles with Different Radioisotopes Labeling for Cancer Theranostics, ACS Nano 2018, 12, 9142-9151.
14.Xuan Yi, Lei Chen, Jie Chen, Debabrata Maiti, Zhifang Chai, Zhuang Liu, Kai Yang*, Biomimetic Copper Sulfide for Chemo-radiotherapy: Enhanced Uptake and Reduced Efflux of Nanoparticles for Tumor Cells under Ionizing Radiation. Advanced Functional Materials. 2018, 28, 1705161.
15.Kai Yang*, Liangzhu Feng, Zhuang Liu*, Stimuli responsive drug delivery systems based on nano-graphene for cancer therapy. Advanced Drug Delivery Reviews, 2016, 105: 228–241.
16.Xuan Yi, Kai Yang*, Chao Liang, Xiaoyan Zhong, Ping Ning, Guosheng Song, Dongliang Wang, Cuicui Ge, Chunying Chen, Zhifang Chai, Zhuang Liu *, Imaging-Guided Combined Photothermal and Radiotherapy to Treat Subcutaneous and Metastatic Tumors Using Iodine-131-Doped Copper Sulfide Nanoparticles. Advanced Functional Materials. 2015, 25, 4689–4699.
18.Guosheng Song, Chao Liang, Hua Gong , Meifang Li , Xianchuang Zheng , Liang Cheng, Kai Yang* , Xiqun Jiang , Zhuang Liu *, Core-Shell MnSe@Bi 2Se3 Fabricated via a Cation Exchange Method as Novel Nanotheranostics for Multimodal Imaging and Synergistic Thermoradiotherapy, Advanced Materials, 2015, 27, 6110–6117.