Ph.D. Supervisor

Phone number: 0512-65880035

Fax number: 0512-65880035

e-mail: zfchai@suda.edu.cn

Mailing address: Room B302, Building 402, Soochow University, 199 Ren'ai Road, Suzhou Industrial Park. Postcode 215123

Professor Zhifang Chai (Academician of the Chinese Academy of Sciences) is the director of the State Key Laboratory of Radiation Medicine and Protection, and the dean of the School for Radiation Medicine and Protection, Radiological＆Interdisciplinary Sciences, Soochow University. Prof. Chai graduated from Fudan University in 1964, majored in radiochemistry. During 1980-1982, he was sponsored by the Humboldt Foundation and engaged in the research of nuclear technology and its application at the Cologne University, Germany. After that, he successively worked at Purdue University in US, Strassburg Nuclear Research Center in France, Delft University and ECN Energy Research Center in Netherlands, and Tokyo Metropolitan University in Japan. He has devoted himself to the development of nuclear technology and nuclear analysis methodology and applied them in several interdisciplinary fields. His representative achievements cover the research area of the molecular-neutron activation analysis of several important elements, the abundance characteristics of platinum group elements, metallonomics, environmental toxicology and nano-safety, fast neutron spectroscopy at nuclear explosion sites, and so on. Prof. Chai is closely engaged in the research of radiopharmaceuticals, nuclear chemistry and nano-biological effects. He is/has been in charge of several major research plans/programs and state key programs of the National Natural Science Foundation. Till now, he has authored/co-authored over  600 papers, including Nature and Nature titled journals, Chem Soc Rev, PNAS, JACS, Nano Lett, etc., as well as 8 Chinese books and 5 English books, and given more than 60 plenary or keynote presentations at important international conferences.He is/was the Titular Member of IUPAC, a Fellow of RSC, and a member or advisor of other 5 international Scientific Societies. He is also a member of the editorial board of 4 international journals, such as Radiochimica Acta, Metallomics, and 10 domestic journals. Prof. Chai is a member of the National anti-Nuclear Terrorism Group of China. So far, Prof. Chai has won 9 national and ministerial level awards, including the National Science Conference Award, the Second Prize of National Natural Science Award, the Second Prize of National Science and Technology Progress, and the First Natural Science Prize of Chinese Academy of Sciences. In 2005, he was awarded the George von Hevesy Award-the premier international award in the field of radioanalytical chemistry and nuclear chemistry, becoming the first winner of this prize from the developing countries.He was awarded the title of the highly cited scientists in the field of pharmacology and toxicology by Thomson Reuters in 2014 and by Elsevier in 2016.Now, he is in charge of the major program of “Research on the Chemistry of Actinide Elements in Complex Systems for Spent Fuel Reprocessing” supported by the National Natural Science Foundation, the Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Suzhou "Famous City, Famous School" project, and so on.

Main research directions:

1. Research on the biological effect of high LET rays;

2. Research on nuclear imaging methodology;

3. Environmental radiochemistry;

4. Research on the biological effects of nanomaterials;

5. Application of nano drugs in radioactive medicine.

Research projects:

1.Project supported by Ministry of Science and Technology; Title: “State Key Laboratory of Radiation Medicine and Protection Jointly Established by the Provincial and Ministry”; Year: 2018.01-2022.12; Funding: 153 million RMB; Research in progress; Director.

2.Project supported by The major program of National Natural Science Foundation; Title: “Research on the Chemistry of Actinide Elements in Complex Systems for Spent Fuel Reprocessing”; No. 21790370; Year: 2018.01-2022.12; Funding: 16.69 million RMB; Research in progress; Director.

3. Project supported by Provincial Department of Education; Title: “the Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions”; No. SX12800114; Year and Funding:2014.01-2017.12,40 million RMB; 2018.01-2021.12, 32 million RMB; Research in progress; Director.

4. Project supported by Provincial Government; Title: “A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)”; No. YX12800211; Year and Funding: 2014.01-2017.12, 20 million RMB; 2018.01-2021.12, 23.6 million RMB; Research in progress; Director.

5. Project supported by the major research plan of National Natural Science Foundation; Title: “Fuel Proliferation and Transmutation of Advanced Nuclear Fission Energy”; No. 91026000; Year: 2011.01-2017.12; Funding: 190 million RMB; Project completed; Director.

Representative articles:

1. Zhang M, Chen J, Zhang S, Zhou X, He L, Sheridan MV, Yuan M, Zhang M, Chen L, Dai X, Ma F, Wang J, Hu J, Wu G, Kong X, Zhou R, Albrecht-Schmitt TE, Chai Z, Wang S. Electron Beam Irradiation as a General Approach for the Rapid Synthesis of Covalent Organic Frameworks under Ambient Conditions. J Am Chem Soc. 2020 May 5. doi: 10.1021/jacs.0c03941.

2. Wang X, Dai X, Shi C, Wan J, Silver MA, Zhang L, Chen L, Yi X, Chen B, Zhang D, Yang K, Diwu J, Wang J, Xu Y, Zhou R, Chai Z, Wang S. A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo. Nat Commun., 2019; 10(1):2570.

3. Chong Y, Dai X, Fang G, Wu R, Zhao L, Ma X, Tian X, Lee S, Zhang C, Chen C, Chai Z, Ge C, Zhou R.Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment.Nat Commun., 2018; 9(1):4861.

4. Yi X, Xu M, Zhou H, Xiong S, Qian R, Chai Z, Zhao L, Yang K. Ultrasmall Hyperbranched Semiconducting Polymer Nanoparticles with Different Radioisotopes Labeling for Cancer Theranostics. ACS Nano, 2018; 12(9):9142-9151.

5. Cheng X, Sun R, Yin L, Chai Z, Shi H*, and Gao M*. Light-triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo. Adv. Mater., 2016; 29: 1604894.

Awards:

1. 1978, “Measurement of the Fast Neutron Excitation Curve of Certain Nuclear”; National Science Conference Award, rank 4th;

2. 1978, “Research on the Protection of Water System in Guanting Reservoir ”; National Science Conference Award, rank 3rd;

3. 1983, “A Comprehensive Study of the Beijing-Tianjin-Bohai Region Environment”; the second prize of the National Science and Technology Progress Award, rank 6th;

4. 1988, “the Application of Nuclear Analytical Technology in Environmental Monitoring”; the second prize of the Science and Technology Progress Award of the Chinese Academy of Sciences, rank 1st;

5. 1991, “Research on the Abundance Characteristics of Platinum Group Elements”; the first prize of the Natural Science of the Chinese Academy of Sciences, rank 1st;

6. 1992, “Research on Molecular Activation of Iridium Chemical Species”; American Nuclear Society Individual Award, rank 1st;

7. 1999, “Research on the Molecular Activation of Several Important Elements”; the second prize of the Natural Science Award of the Chinese Academy of Sciences, rank 5th;

8. 2012, “Nano biological Safety Research”; National Natural Science Second Prize, rank 5th;

9. 2014, Thomson Reuters Highly Cited Scientist in the field of pharmacology and toxicology;

10. 2015, Medical Director Award of Suzhou University, rank 1st;

11. 2019, the Outstanding Scientific and Technological Achievement Award of the Chinese Academy of Sciences (College of Nanobiological Effects and Safety Research).

Teaching activities and enrollment information:

1. Progress of Radiation Medicine (An undergraduate course for students majored in Seven-year Clinical Medicine (Radiation Medicine))

2. Introduction of Nuclear Science (An undergraduate course)

3. Lectures on the Frontiers of Medicine and Life Sciences (A doctoral course).