Reporter: Prof. Fan Zhang

Time：November 27, 2021, 10:00 a.m.

Place：Meeting room of 1st floor, Building 401, Soochow University at Dushu

 Lake

Welcome to attend the seminar!

School for Radiological＆Interdisciplinary Sciences, Soochow University

Short Bio:

Professor Fan Zhang Fan Zhang received his PhD in 2008 from Fu Dan University followed by more than 2 years postdoctoral experience (2008-2010) in University of California at Santa Barbara before joining as an professor in the Chemistry Department of Fu Dan University in 2010. In 2020, Shanghai Biomedical Testing Reagents Engineering Research Center was established as the director of the center.

Research Fields and Achievements

His current research interests include bioanalysis, bioimaging, drug delivery, disease diagnosis and therapy. Prof. Zhang has authored a number of book chapters, patents and more than 100 peer-reviewed research papers in international journals with the high impact factors with 17000 citations and authored 2 English books. He has won the first prize of National Natural Science award (the fourth completion person), the first prize of Natural Science of Ministry of Education, Hou Debang Chemical Technology Award, Shanghai Science and Technology Progress Award, Shanghai Young Talents Science and Technology Award and other honors.

Report Summaries

Deep tissue imaging in the second near-infrared (NIR-II) window holds great promise for physiological studies and biomedical applications. However, inhomogeneous signal attenuation due to biological matter hampers the application of multiple-wavelengths NIR-II probes to multiplexed imaging. Here we present lanthanide-doped NIR-II nanoparticles with engineered luminescence lifetimes for in vivo quantitative imaging using time-domain multiplexing. We demonstrate that robust lifetime coding is independent of tissue penetration depth, and we apply in vivo multiplexing to identify tumor subtypes in living mice. Our results correlate well with standard ex vivo immunohistochemistry assays, suggesting that luminescence lifetime imaging could be used as a minimally invasive approach for disease diagnosis.